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OBJECTIVE: To explore the mediating effect of life satisfaction between psychological resilience and depression among medical staffs.METHODS: A total of 472 medical staffs in Shaoguan City were selected as the study subjects by convenience sampling method. The mental health, life satisfaction and depression were investigated and analyzed using the Psychological Resilience Questionnaire, Life Satisfaction Questionnaire and Self-Rating Depression Scale. RESULTS: The scores of mental resilience, life satisfaction and depression were 79.3±17.1, 16.1±6.1 and 53.5±11.8, respectively. There was a negative correlation between mental resilience score and depression score in medical staffs [correlation coefficient(r)=-0.638,P<0.01]. The score of life satisfaction was positively correlated with the scores of mental resilience and its three dimensions of toughness, strength and optimism(r were 0.341, 0.313, 0.306 and 0.336 respectively, all P<0.01). The score of life satisfaction was negatively correlated with the score of depression(r=-0.474,P<0.01). The life satisfaction had mediating role between mental resilience and depression, with the mediating effect value of-0.059, accounting for 13.50% of the total effect. CONCLUSION: Life satisfaction plays a partial intermediary role between mental resilience and depression in medical staffs.
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Objective In laparoscopic cholecystectomy(LC), increased intra-abdominal pressure and carbon dioxide absorption may cause obvious sympathetic excitation and bring about increased blood pressure and heart rate. Effective control on such sympathetic responses can reduce complications, which is beneficial to timely recovery for patients. The study aimed to investigate the effect of different doses of dexmedetomidine on blood pressure, heart rate and postoperative sedation during perioperative period in patients undergoing LC.Methods Sixty patients enrolled in the study randomly were divided into three equal groups(20 patients each): control group(only equal amount of isotonic saline), low dose group and high dose group according to the injection of dexmedetomidine. At each time point including before anaesthesia(T0), before cutting(T1), pneumoperitoneum at 0min(T2), at 10min(T3), at 20min(T4), immediate deflation(T5), before extubation(T6), after extubation and before leaving operation room(T7), and entering recovery room(T8), records were made on the patient’s blood pressure, heart rate, SpO2, airway peak pressure, PetCO2 and Ramsay sedation score after extubation.Results Extubation time and PACU stay time were significantly longer in high dose group in comparison with control group and low dose group (F=12.669, P=0.000 and F=6.281, P=0.030 respectively). Compared with control group, the heart rates of high dose group and low dose group at T5, T7 and T8 decreased significantly(P<0.05). During T2-T5, airway peak pressure was significantly higher than those of control group and low dose group(P<0.05). At T7, the Ramsay score of high dose group was significantly higher than those of control group and low dose group(P=0.015).Conclusion Sustainable pumping of dexmedetomidine can keep stable heart rate. However, the increase of pumping rate and dose will deepen the depth of sedation after extubation and obviously extend extubation time and observation time in recovery room. Therefore, it is appropriate to infuse dexmedetomidine less than 0.5μg/(kg·h) in clinical anaesthesia.
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This study aimed to observe the protective effects of sufentanil pretreatment on rat cerebral injury during cardiopulmonary bypass [CPB] and to explore the underlying mechanism. Twenty-four male adult Sprague Dawley [SD] rats were divided into 4 groups. Then, the rat CPB model was established. A 14G trocar was inserted into the atrium dextrum. For rats in S1 and S5 groups, sufentanil [1 microgKg[-1] and 5 microgKg[-1]] were applied before CPB process. After the operation, rat brain samples were harvested for measurement of the water content of the brains, total calcium in brain tissue and the level of serum S100beta. Compared with the Sham group, the water content and the total calcium of the brain tissue, and the expression of S100beta in serum were significantly increased in the CPB group [P<0.05]. Compared with the CPB group, sufentanil treatment significantly reduced the water content of the brains, the total calcium and S100beta expression [P<0.05]. The blood pressure and heart rate were significantly decreased in groups CPB, S1, and S5 compared with Sham group during CPB. Compared with the Sham group, the levels of pH and blood lactate in other groups were decreased and increased, respectively, in the post-CPB period. During the CPB and post-CPB periods, the hematocrit levels were significantly down-regulated in groups CPB, S1, and S5 compared with Sham group. In conclusion, sufentanil pretreatment was effective in reducing the cerebral injury during CPB. Reduction in calcium overload may be a potential mechanism in such process